Katedra i Zakład Biochemii

Wydział Lekarski

Katedra i Zakład Biochemii

Wydział Lekarski

Publikacje

ZESPÓŁ  PUBLIKACJE  PROJEKTY   KONTAKT I WSPÓŁPRACA PRACOWNIA I USŁUGI

2025

  • Zhylko A, Morawski M, Rykowski P, Krasnodębski M, Wyporski A, Borkowski J, (...), Kobryń K, Stankiewicz R, Stypułkowski J, Hołówko W, Patkowski W, Wróblewski T, Szczepankiewicz B, Górnicka B, Mielczarek-Puta M, Struga M, Krawczyk M, Grąt M. Real-time biomarkers of liver graft quality in hypothermic oxygenated machine perfusion. Journal of Clinical Medicine. 2025;14(2):1-17.
  • Safi K, Pawlicka A, Pradhan B, Sobieraj J, Zhylko A, Struga M, Grąt M, Chrzanowska A. Perspectives and Tools in Liver Graft Assessment: A Transformative Era in Liver Transplantation. Biomedicines. 2025;13(2):1-28.
  • Lim G, Grosicka-Maciąg E, Szumiło M, Graska D, Rahden-Staroń I, Kurpios-Piec D. The Modulatory Effect of Selol (Se IV) on Pro-Inflammatory Pathways in RAW 264.7 Macrophages. International Journal of Molecular Sciences. 2025;26(2):1-16.
  • Jędrzejczyk M, Sulik M, Mielczarek-Puta M, Lim G, Podsiad M, (...), Struga M, Huczyński A. Anticancer activity of salinomycin quaternary phosphonium salts. European Journal of Medicinal Chemistry. 2025;282:1-18.

2024

  • Martula E, Morak-Młodawska B, Jeleń M, Strzyga-Łach P, Struga M, Żurawska K, Kasprzycka A, Bagrowska W. Comparative Analysis of Structural Analogs of Dipyridothiazines with m-Xylene and a Lutidine Moiety—In Silico, In Vitro, and Docking Studies. Applied Sciences. 2024;14(16):1-14.
  • Madetko-Alster N, Otto-Ślusarczyk D, Struga M, Kutyłowski M, Drzewińska A, Duszyńska-Wąs K, Migda B, Alster P. Glucose Metabolism and Cognitive Decline in Progressive Supranuclear Palsy and Corticobasal Syndrome: A Preliminary Study. Journal of Clinical Medicine. 2024;13(2):1-14.
  • Strzyga-Łach P, Kurpios-Piec D, Chrzanowska A, Szczepaniak J, Bielenica A. 1,3-Disubstituted thiourea derivatives: Promising candidates for medicinal applications with enhanced cytotoxic effects on cancer cells. European Journal of Pharmacology. 2024;982:1-8.
  • Alster P, Otto-Ślusarczyk D, Wiercińska-Drapało A, Struga M, Madetko-Alster N. The potential significance of hepcidin evaluation in Progressive Supranuclear Palsy. Brain and Behavior. 2024;14(6):1-5.
  • Jędrzejczyk M, Morabito B, Żyżyńska-Granica B, Struga M, Janczak J, Aminpour M, Tuszynski J, Huczyński A. Novel Combretastatin A-4 Analogs—Design, Synthesis, and Antiproliferative and Anti-Tubulin Activity. Molecules. 2024;29(10):1-22.
  • Morawski M, Zhylko A, Rykowski P, Krasnodębski M, Hołówko W, Lewandowski Z, Mielczarek-Puta M, Struga M, Szczepankiewicz B, Górnicka B, Krawczyk M, Grąt M. Routine end-ischemic hypothermic machine perfusion in liver transplantation from donors after brain death: results of 2-year follow-up of a randomized controlled trial . International Journal of Surgery. 2024;110(11):7003-7010.
  • Sulik M, Otto-Ślusarczyk D, Antoszczak M, Struga M, Huczyński A. Ivermectin and its synthetic derivatives – A new class of anticancer agents. European Journal of Medicinal Chemistry Reports. 2024;12:1-11.
  • Alster P, Otto-Ślusarczyk D, Kutyłowski M, Migda B, Wiercińska-Drapało A, Jabłońska J, Struga M, Madetko-Alster N. The associations between common neuroimaging parameters of Progressive Supranuclear Palsy in Magnetic Resonance Imaging and non-specific inflammatory factors – pilot study. Frontiers in Immunology. 2024;15:1-7..
  • Napiórkowska M, Otto-Ślusarczyk D, Kurpios-Piec D, Stukan I, Gryzik M, Wojda U. BM7, a derivative of benzofuran, effectively fights cancer by promoting cancer cell apoptosis and impacting IL-6 levels. European Journal of Pharmacology. 2024;978:1-11.
  • Szostek T, Otto-Ślusarczyk D, Roszkowski P, Struga M, Szulczyk D. Exploring the bioactive potential of (2-imino-4-oxo-1,3-thiazolidin-5-yl)acetic acid derivatives: A comprehensive review. Results in Chemistry. 2024;11:1-11.
  • Alster P, Otto-Ślusarczyk D, Szlufik S, Duszyńska-Wąs K, Drzewińska A, Wiercińska-Drapało A, Struga M, (...), Friedman A, Madetko-Alster N. The significance of glial cell line-derived neurotrophic factor analysis in Progressive Supranuclear Palsy. Scientific Reports. 2024;14:1-9.
  • Chunowski P, Otto-Ślusarczyk D, Duszyńska-Wąs K, Drzewińska A, Załęski A, Madetko-Alster N, Wiercińska-Drapało A, Struga M, Alster P. Possible Impact of Peripheral Inflammatory Factors and Interleukin-1β (IL-1β) on Cognitive Functioning in Progressive Supranuclear Palsy–Richardson Syndrome (PSP-RS) and Progressive Supranuclear Palsy–Predominant Parkinsonism (PSP-P). International Journal of Molecular Sciences. 2024;25(23):1-11.
  • Jeleń M, Otto-Ślusarczyk D, Morak-Młodawska B, Struga M. Novel Tetracyclic Azaphenothiazines with the Quinoline Ring as New Anticancer and Antibacterial Derivatives of Chlorpromazine. International Journal of Molecular Sciences. 2024;25(8):1-26.
  • Dziduch K, Janowska S, Andrzejczuk S, Strzyga-Łach P, Struga M, Feldo M, Demchuk O, Wujec M. Synthesis and Biological Evaluation of New Compounds with Nitroimidazole Moiety. Molecules. 2024;29(13):1-20.

2023

  • Strzyga-Łach P, Chrzanowska A, Kiernozek-Kalińska E, Żyżyńska-Granica B, Podsadni K, Podsadni P, Bielenica A. Proapoptotic effects of halogenated bis-phenylthiourea derivatives in cancer cells. Archiv der Pharmazie. 2023;356(9):1-17.
  • Grąt M, Morawski M, Zhylko A, Rykowski P, Krasnodębski M, Wyporski A, Borkowski J, Lewandowski Z, Kobryń K, Stankiewicz R, Stypułkowski J, Hołówko W, Patkowski W, Mielczarek-Puta M, Struga M, Szczepankiewicz B, Górnicka B, Krawczyk M. Routine End-ischemic Hypothermic Oxygenated Machine Perfusion in Liver Transplantation from Donors After Brain Death: A Randomized Controlled Trial. Annals of Surgery. 2023;278(5):662-668.
  • Chrzanowska A, Kurpios-Piec D, Żyżyńska-Granica B, Kiernozek-Kalińska E, Lay W, Ciechanowicz A, Struga M. Anticancer activity and metabolic alteration in colon and prostate cancer cells by novel moxifloxacin conjugates with fatty acids. European Journal of Pharmacology. 2023;940:1-12.
  • Janowska S, Khylyuk D, Janowski M, Kosikowska U, Strzyga-Łach P, Struga M, Wujec M. Synthesis and Biological Evaluation of New Schiff Bases Derived from 4-Amino-5-(3-fluorophenyl)-1,2,4-triazole-3-thione. Molecules. 2023;28(6):1-21.
  • Napiórkowska M, Kurpios-Piec D, Kiernozek-Kalińska E, Leśniak A, Klawikowska M, Bujalska-Zadrożny M. New aryl-/heteroarylpiperazine derivatives of 1,7-dimethyl-8,9-diphenyl-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5,10-trione: Synthesis and preliminary studies of biological activities. Bioorganic & Medicinal Chemistry. 2023;96:1-14.
  • Madetko-Alster N, Otto-Ślusarczyk D, Wiercińska-Drapało A, Koziorowski D, Szlufik S, Samborska-Ćwik J, Struga M, Friedman A, Alster P. Clinical Phenotypes of Progressive Supranuclear Palsy—The Differences in Interleukin Patterns. International Journal of Molecular Sciences. 2023;24(20):1-12.
  • Struga M, Roszkowski P, Bielenica A, Otto-Ślusarczyk D, Stępień K, Stefańska J, (...), Wrzosek M. N-Acylated Ciprofloxacin Derivatives: Synthesis and In Vitro Biological Evaluation as Antibacterial and Anticancer Agents. ACS Omega. 2023;8(21):18663-18684.
  • Alster P, Madetko-Alster N, Otto-Ślusarczyk D, Migda A, Migda B, Struga M, Friedman A. Role of orexin in pathogenesis of neurodegenerative parkinsonisms. Neurologia i Neurochirurgia Polska. 2023;57(4):335-343.

2022

  • Żyżyńska-Granica B, Mollica A, Stefanucci A, Granica S, Kleczkowska P. Comparative Study of Chemical Stability of a PK20 Opioid–Neurotensin Hybrid Peptide and Its Analogue [Ile9]PK20—The Effect of Isomerism of a Single Amino Acid. International Journal of Molecular Sciences. 2022;23(18):1-14.
  • Chrzanowska A, Olejarz W, Kubiak-Tomaszewska G, Ciechanowicz A, Struga M. The Effect of Fatty Acids on Ciprofloxacin Cytotoxic Activity in Prostate Cancer Cell Lines—Does Lipid Component Enhance Anticancer Ciprofloxacin Potential? Cancers. 2022;14(2):1-21.
  • Kubiak-Tomaszewska G, Roszkowski P, Grosicka-Maciąg E, Strzyga-Łach P, Struga M. Effect of Hydroxyl Groups Esterification with Fatty Acids on the Cytotoxicity and Antioxidant Activity of Flavones. Molecules. 2022;27(2):1-13.
  • Antoszczak M, Otto-Ślusarczyk D, Kordylas M, Struga M, Huczyński A. Synthesis of Lasalocid-Based Bioconjugates and Evaluation of Their Anticancer Activity. ACS Omega. 2022;7(2):1943-1955.
  • Rymuza J, Gutowska K, Kurpios-Piec D, Struga M, Miśkiewicz P. Decrease in Bone Formation and Bone Resorption during Intravenous Methylprednisolone Pulse Therapy in Patients with Graves’ Orbitopathy. Journal of Clinical Medicine. 2022;11(17):1-13.
  • Chrzanowska A, Struga M, Roszkowski P, (...), Jałbrzykowska K, (...), Stefańska J, (...), Wrzosek M, Bielenica A. The Effect of Conjugation of Ciprofloxacin and Moxifloxacin with Fatty Acids on Their Antibacterial and Anticancer Activity. International Journal of Molecular Sciences. 2022;23(11):1-28.
  • Kalinowska D, Klepka M, Szulczyk D, Mielczarek-Puta M, Struga M. Complexes of 1,5-Disubstituted Tetrazole Derivatives with Cu(Ii) Ions: The Molecular Structure Determination by Xas Spectroscopy with the Cytotoxic and Microbiological Activity Evaluation. SSRN. 2022:1-18.
  • Grinkevich V, Vema A, Fawkner K, (...), Zawacka-Pankau J. Novel Allosteric Mechanism of Dual p53/MDM2 and p53/MDM4 Inhibition by a Small Molecule. Frontiers in Molecular Biosciences. 2022;9:1-15.
  • Drzewiecka-Antonik A, Struga M, Głogowska A, (...), Dobrzyńska K, Chrzanowska A, (...), Wrzosek M, Bielenica A. Synthesis, Structural Characterization and Biological Activity Evaluation of Novel Cu(II) Complexes with 3-(trifluoromethyl)phenylthiourea Derivatives. International Journal of Molecular Sciences. 2022;23(24):1-19.

2021

  • Abram M, Rapacz A, Latacz G, Szulczyk B, (...), Otto-Ślusarczyk D, Struga M, (...), Kamiński K. Asymmetric synthesis and in vivo/in vitro characterization of new hybrid anticonvulsants derived from (2,5-dioxopyrrolidin-1-yl)phenylacetamides. Bioorganic Chemistry. 2021;109:1-15.
  • Zagórska A, Czopek A, Jaromin A, Mielczarek-Puta M, Struga M, Stary D, Bajda M. Design, Synthesis, and In Vitro Antiproliferative Activity of Hydantoin and Purine Derivatives with the 4-Acetylphenylpiperazinylalkyl Moiety. Materials. 2021;14(15):1-15.
  • Otto-Ślusarczyk D, Graboń W, Mielczarek-Puta M, Chrzanowska A, Barańczyk-Kuźma A. Influence of oxygen availability on expression of glutaminolysis genes in human colon cancer cells. Postępy Higieny i Medycyny Doświadczalnej. 2021;75(1):923-932.
  • Kurpios-Piec D, Czeczot H, Podsiad M. Protective effect of quercetin and luteolin on LPS-induced oxidative stress in RAW 264.7 cells. Acta Poloniae Pharmaceutica - Drug Research. 2021;78(4):527-538.
  • Kulik K, Żyżyńska-Granica B, Kowalczyk A, Kurowski P, Gajewska M, Bujalska-Zadrożny M. Magnesium and Morphine in the Treatment of Chronic Neuropathic Pain–A Biomedical Mechanism of Action. International Journal of Molecular Sciences. 2021;22(24):1-14.
  • Szulczyk D, Bielenica A, Roszkowski P, Dobrowolski M, Olejarz W, Kmiecik S, Podsiad M, Struga M. Synthetic Transition from Thiourea-Based Compounds to Tetrazole Derivatives: Structure and Biological Evaluation of Synthesized New N-(Furan-2-ylmethyl)-1H-tetrazol-5-amine Derivatives. Molecules. 2021;26(2):1-
  • Gumieniczek A, Berecka-Rycerz A, Fornal E, Żyżyńska-Granica B, Granica S. Comprehensive Insight into Chemical Stability of Important Antidiabetic Drug Vildagliptin Using Chromatography (LC-UV and UHPLC-DAD-MS) and Spectroscopy (Mid-IR and NIR with PCA). Molecules. 2021;26(18):1-28.
  • Kurpios-Piec D, Majewska-Wierzbicka M, Czeczot H, Podsiad M. Flavonoids as hydroxyl radical scavengers, iron reductants and chelators: in vitro antioxidant action. Acta Poloniae Pharmaceutica - Drug Research. 2021;78(5):635-648.
  • Otto-Ślusarczyk D, Mielczarek-Puta M, Graboń W. The Real Cytotoxic Effect of Artemisinins on Colon Cancer Cells in a Physiological Cell Culture Setting. How Composition of the Culture Medium Biases Experimental Findings. Pharmaceuticals. 2021;14(10):1-15.
  • Chrzanowska A, Drzewiecka-Antonik A, Dobrzyńska K, Stefańska J, Pietrzyk P, Struga M, Bielenica A. The Cytotoxic Effect of Copper (II) Complexes with Halogenated 1,3-Disubstituted Arylthioureas on Cancer and Bacterial Cells. International Journal of Molecular Sciences. 2021;22(21):1-25.
  • Otto-Ślusarczyk D, Graboń W, Mielczarek-Puta M, Chrzanowska A. Teriflunomide – The common drug with underestimated oxygen - Dependent anticancer potential. Biochemistry and Biophysics Reports. 2021;28:1-6.
  • Chrzanowski J, Chrzanowska A, Graboń W. Glycyrrhizin: An old weapon against a novel coronavirus. Phytotherapy Research. 2021;35(2):629-636.
  • Czerwonka D, Mielczarek-Puta M, Antoszczak M, Cioch A, Struga M, Huczyński A. Evaluation of the anticancer activity of singly and doubly modified analogues of C20-epi-salinomycin. European Journal of Pharmacology. 2021;908:1-10.
  • Strzyga-Łach P, Chrzanowska A, Podsadni K, Bielenica A. Investigation of the Mechanisms of Cytotoxic Activity of 1,3-Disubstituted Thiourea Derivatives. Pharmaceuticals. 2021;14(11):1-17.