Projekty

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ONGOING PROJECTS:

  • iTune – Immunity of Tumors, New Multi-modal Explorations.

PIs: Dr. Pyrzynska B. and Dr. Zerrouqi A.; Polish National Agency for Academic Exchange (NAWA; Poland); Strategic Partnership grant.

  • Innovative methods for risk assessment and prevention of cytokine release syndrome (CRS) as a complication of CAR-T cell therapy.

PI: Prof. Ratajczak M.Z; Dr. Pyrzynska B. – Coordinator of Tasks; Medical Research Agency (ABM, Poland); ABM/03/KPO.

  • Effects of a cancer metabolite on the immune response.

PI: Dr. Zerrouqi A.; National Science Centre (NCN, Poland); grant OPUS20.

  • Testing of cation carrier derivatives as prospective therapeutic agents for the treatment of B-cell-derived malignancies.

PI: Dr. Pyrzynska B.; National Science Centre (NCN, Poland); grant OPUS18.
 

 

COMPLETED PROJECTS:

  •  EVIONA - Extracellular Vesicles in Immuno-Oncology

PIs: Dr. Pyrzynska B. and Dr. Czystowska-Kuzmicz M.; Polish National Agency for Academic Exchange (NAWA; Poland); International Academic Partnership; 2019-2022; https://eviona.wum.edu.pl/en/node/116

  • NK cells with inducible expression of CAR as a novel immunotherapy, increasing the efficacy of monoclonal antibodies.

PI: Dr. Pyrzynska B.; National Science Centre (NCN, Poland); OPUS12 grant; 2017-2022;

  • Strategies to overcome immunosuppression in immunotherapy of cancer.

PI: Dr. Zerrouqi A.; Ministry of Science and Higher Education (MNiSW, Poland); Innovation Incubator 2.0, 2020.

  • Effects of selected chemotherapeutics on the efficacy of anti-CD20 immunotherapy in B cell-derived malignancies.

PI: Miazek N., MSc; Dr. Pyrzynska B.- Supervisor; Ministry of Science and Higher Education (MNiSW, Poland); Diamond Grant; 2016-2019;

  • STREAM (Strategies towards Excellence in Immuno-Oncology)

PI: Prof. Golab J.; Dr. Pyrzynska B. - Leader of Work Package; Horizon 2020 (EU); Twinning; 2016-2018;

  • Influence of AKT signaling pathway on CD20 expression and antitumor activity of therapeutic monoclonal antibodies.

PI: Dr. Pyrzynska B.; National Science Centre (NCN, Poland); OPUS6; 2014-2017;

  • Role of multifunctional adapter proteins APPL1 and APPL2 in the regulation of cell growth and tumor properties.

PI: Dr. Pyrzynska B.; Ministry of Science and Higher Education (MNiSW, Poland); research project; 2010-2013.

 

Recent external collaborations:

  • International Centre for Genetic Engineering and Biotechnology (ICGEB) in Trieste, Italy, collaboration with Prof. Dimitar Efremov in the field of immuno-oncology.
  • University of Pennsylvania in Philadelphia, USA, “International Academic Partnership” program (NAWA, Poland), collaboration with Prof. Wei Guo in the field of extracellular vesicles.
  • King’s College London, UK, “International Academic Partnership” program (NAWA, Poland), collaboration with Prof. Tony Ng in the field of extracellular vesicles.
  • The Francis Crick Institute in London, UK, Horizon 2020 (H2020) grant, collaboration with Prof. Dinis Calado in the field of immuno-oncology.
  • INSERM, Centre Recherche en Cancérologie de Marseille, Institut Paoli-Calmettes, Aix-Marseille University, France. collaboration with Dr. Cyril Fauriat in immunology.