TEAM PUBLICATIONS PROJECTS CONTACT LAB
ONGOING PROJECTS;
1. Modeling cancer cell responses using generative proteomic interaction vectors and phenotype prediction with AI
Conducted in collaboration with the Faculty of Mathematics and Information Science at Warsaw University of Technology under the INTEGRA initiative. The project focuses on supporting in vitro/in vivo studies through advanced predictive modeling of cellular responses.
2. Modern drug design using activity cliff–based generative tools
Combines computational design with synthesis and experimental evaluation, enabling more informed identification of promising lead compounds. Includes toxicity prediction to eliminate unsafe candidates early and reduce reliance on animal models in preclinical studies.
3. Design and synthesis of tetrazole–thiourea conjugates with antibacterial activity (including MRSA and Mycobacterium tuberculosis)
The research includes the evaluation of biological activity in in vitro assays against reference and clinical strains, analysis of physicochemical properties (including lipophilicity and logD), as well as ADMET parameters, and molecular modeling to determine the potential mechanism of action. An important component is also the assessment of the safety of the studied compounds, including cytotoxicity studies and their effects on cells.
4. Synthesis of maleimid-piperazines and evaluation of their activity on the central nervous system
The research includes the analysis of cytotoxicity and in vivo studies using the zebrafish (Danio rerio) model, including the assessment of embryotoxicity, as well as effects on development and behavioral responses. Additionally, in silico predictions of the pharmacokinetic and toxicological properties of the studied compounds are conducted.
COMPLETED PROJECTS:
1. Retrospective non-interventional study combined with pharmacoeconomic modeling (Project number 1M9/UK1/463/23)
Conducted at the Department of Experimental and Clinical Pharmacology, Medical University of Warsaw.
2. Synthesis and biological evaluation of new thiazolidinone derivatives with anticancer potential
Conducted within the “Młody Badacz” internal grant program at the Medical University of Warsaw, integrating synthetic chemistry, cancer biology, and computational drug design.